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( RGBP see page ), ( RGBPP ) announced today the filing of a [provisional/nonprovisional] utility patent application with the United States Patents and Trademark Office covering NR2F6-silenced CAR T cells. While previous work demonstrated that methodologies developed by Regen and covered under its issued patent #9,091,696 are useful in stimulation of T cell activity, the current patent further modifies T cells to express molecules that act as a localized “danger signal” to the immune system. CAR T cells are T Cells (T lymphocytes ) which are genetically engineered to produce chimeric antigen receptors (CARs) on their surface. CARs are proteins that allow the T cells to recognize an antigen on targeted tumor cells. Remarkable clinical results have been obtained by numerous investigators utilizing CAR T cells in the treatment of leukemias and lymphomas[1]. Unfortunately, results for solid tumors have been limited[2]. This is thought to occur because solid tumors produce numerous immune-suppressive factors that coax the cells that surround the tumor to protect the tumor against the immune response. By utilizing NR2F6-silencing methods, Regen believes it has developed a new method of augmenting the cells that surround the tumor to allow for immune destruction of the tumor to occur. “When we look at other chronic diseases, it is important to note that effective treatment protocols always involve multifactorial attacks on the disease process.

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